Tadoule Lake (Chipewyan: ᕞᐡ ᗀᐅᐟᕄ ᕤᐧᐁ, T’es he úli túé) is an isolated northern community in Manitoba reachable by plane, snowmobile, dog team sleds, and in winter by winter road. In 1973, the Sayisi Dene moved here to return to their Barren-ground Caribou hunting life.

The name appears as Tos-da-ool-le in the T.B. Johnson report of 1890, and as Tas-da-ool-le on the Arrowsmith map of 1832. Of Chipewyan origin Tes-He-Olie Twe, it may be translated as "floating charcoal" for the floating cinders and burnt wood resulting from an early forest fire or "Ashes floating on the lake". The modern spelling has been in common usage since 1914.

The community is located on the northwest shore of Tadoule Lake by the Seal River and is centered within the winter range of the Qamiuriak Caribou Herd (barren-ground caribou). Tadoule Lake is served by Tadoule Lake Airport for air transportation and the Peter Yassie Memorial School for K-12 education.

The Sayisi Dene First Nation Relocation Settlement Trust has funded annual children's summer camps intended to promote literacy since 2016, which are well attended by the community.

In recent years, Tadoule Lake is exploring the possibility of youth wilderness expeditions for the community to explore the Seal River Watershed. The Sayisi Dene and neighbouring Inuit and Cree communities are attempting to establish the watershed in which Tadoule Lake is located in to become an Indigenous Protected Conservation Area.

During 2021 Western North America heat wave, on July 2 and 3, 2021, the record high temperature of 38.1 °C (100.6 °F) was registered.